Key result
DISC1 HEP3 haplotype linked to lower schizophrenia risk exclusively in females.
Why the study?
Previous linkage analysis identified a peak on 1q42 in Finnish schizophrenia families, motivating investigation of candidate genes TRAX, DISC1, and DISC2 for association with schizophrenia.
Observational (n=458)
p-value: p=0.0031
The DISC1 gene haplotype HEP3 is associated with a protective effect against schizophrenia, particularly in females, in a Finnish population.
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No immediate clinical implications for schizophrenia risk assessment; extends DISC1 haplotype evidence with sex-specific effects requiring replication.
William Hennah (2003) conducted an observational in Schizophrenia (n=458). DISC1 gene haplotype (HEP3) was evaluated on Transmission of HEP3 haplotype to affected individuals (p=0.0031). The HEP3 haplotype of the DISC1 gene was significantly under-transmitted to individuals affected by schizophrenia (P=0.0031), with the effect being significant only in affected females (P=0.00024).
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