Key result
Low tension glaucoma is linked to a ~7 mm Hg orthostatic systolic drop versus OAG and controls.
Why the study?
Low tension glaucoma (LTG) may result from a hemodynamic crisis or chronic occlusive disease, but cardiovascular characteristics in LTG patients remain unclear.
Do patients with low tension glaucoma have particular cardiovascular characteristics compared to those with open angle glaucoma or controls?
Comparison
LTG patients versus OAG patients and control patients
Design
Case-control study
Authors
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Orthostatic BP monitoring may warrant consideration in low-tension glaucoma; leaves open whether autonomic dysfunction contributes to progression.
Case-Control (n=148)
Do patients with low tension glaucoma have particular cardiovascular characteristics compared to those with open angle glaucoma or controls?
Absolute Event Rate: -6.9% vs -1.2%
Patients with low tension glaucoma exhibit significantly greater postural hypotension compared to those with open angle glaucoma or controls, suggesting a potential role in its pathogenesis.
Demailly et al. (2010) conducted a case-control in Low tension glaucoma (n=148). Low tension glaucoma vs. Open angle glaucoma and healthy controls was evaluated on Mean difference of systolic blood pressure between standing and lying positions. Patients with low tension glaucoma had a significantly greater mean drop in systolic blood pressure upon standing (-6.9 mm Hg) compared to those with open angle glaucoma (-1.2 mm Hg) and controls (-1.5 mm Hg).
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