Key result
Myosin-18B deletion disrupts myosin II stack assembly, impairing actomyosin bundle maturation and cell migration.
Why the study?
Mechanisms underlying the assembly of myosin II stacks and their physiological functions have remained elusive.
Myosin-18B plays a critical role in the assembly of myosin II stacks, which is essential for the maturation of contractile actomyosin bundles and vital cellular processes.
No takes yet. Share an insight, caveat, or question.
Myosin-18B findings in animal cells warrant no practice change; leaves open its relevance to human cardiovascular cytoskeletal disorders.
Jiu et al. (2018) studied Osteosarcoma cells. Myosin-18B deletion vs. Wild-type cells was evaluated on Assembly of myosin II stacks and maturation of actomyosin bundles. Myosin-18B deletion severely impaired the assembly of myosin II stacks, resulting in defective maturation of actomyosin bundles and abnormal cell morphogenesis and migration.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: