What question did this study set out to answer?

To describe the clinical, histological, and genetic characteristics of a female dog exhibiting virilization and reproductive tract abnormalities.

November 28, 2022Journal of Applied GeneticsOpen Access

Non-mosaic X monosomy (77,X) in a female dog with signs of virilization

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To describe the clinical, histological, and genetic characteristics of a female dog exhibiting virilization and reproductive tract abnormalities.
Evaluated a 14-month-old female Miniature Poodle presenting with an enlarged clitoris and teat asymmetry through macroscopic and histopathological examination of reproductive organs.
Performed cytogenetic chromosome analysis and validated the chromosomal complement using droplet digital PCR (ddPCR).
Screened genomic DNA from peripheral blood and ovarian tissue for Y-chromosome-specific genes (SRY, ZFY, and TSPY1).
Cytogenetic analysis established a pure, non-mosaic 77,X karyotype (X monosomy), which was confirmed by ddPCR.
Histopathological evaluation revealed ovarian parenchyma effaced by diffuse theca cell hyperplasia with atretic primary follicles, alongside macroscopically normal uterine and fallopian tube structures.
Molecular assays confirmed the complete absence of male-determining Y-linked genes (SRY, ZFY, and TSPY1) in both blood and ovarian tissue despite phenotypic virilization.

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Implication

Case report reveals non-mosaic X monosomy without Y-linked genes in a virilized female dog, highlighting atypical mechanisms of canine sexual development.

Cite This Study

Szczerbal et al. (2022) studied this question.

synapsesocial.com/papers/6aaba9f2bf7b76dfa6834f3a https://doi.org/10.1007/s13353-022-00739-3

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Implication

Case report reveals non-mosaic X monosomy without Y-linked genes in a virilized female dog, highlighting atypical mechanisms of canine sexual development.

Non-mosaic X monosomy (77,X) in a female dog with signs of virilization

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Discussion

Implication

Cite This Study

Non-mosaic X monosomy (77,X) in a female dog with signs of virilization

Key Points

Discussion

Implication

Cite This Study

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