Key result
MCG poorly diagnoses functional ischemia and significant stenosis but shows high sensitivity for mild atherosclerosis.
Why the study?
The clinical utility of Multifunction Cardiogram (MCG) for diagnosing functional myocardial ischemia and angiographically significant stenosis was unclear.
Does Multifunction Cardiogram (MCG) accurately diagnose functional myocardial ischemia and angiographic coronary atherosclerosis compared to angiography?
Does Multifunction Cardiogram (MCG) accurately diagnose functional myocardial ischemia and angiographic coronary atherosclerosis compared to angiography?
While MCG has poor diagnostic performance for detecting significant coronary stenosis, it demonstrates high sensitivity for identifying mild angiographic coronary atherosclerosis.
Does not support MCG for ischemia or ≥50% stenosis decisions; leaves open its role in milder atherosclerosis detection.
This study showed poor diagnostic performance of MCG for functional myocardial ischemia and angiographically significant stenosis (≥50% by quantitative coronary angiography). However, we reported high sensitivity to detect angiographic coronary atherosclerosis (defined as coronary stenosis ≥30% by visual estimation, which was the threshold % diameter stenosis to perform invasive FFR measurement in MED-FIT) in a post hoc subanalysis using the MED-FIT data.14 These are not contrasting conclusions. Therefore, we believe that the MED-FIT study added important information about the clinical utility of MCG.
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Kawaji et al. (2015) conducted a letter in Functional Myocardial Ischemia. Multifunction Cardiogram (MCG) was evaluated on Diagnostic performance for functional myocardial ischemia and angiographically significant stenosis (≥50%). Multifunction Cardiogram (MCG) showed poor diagnostic performance for functional myocardial ischemia and ≥50% stenosis, but high sensitivity for detecting ≥30% coronary atherosclerosis.
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