Key result
Each additional unfavorable SDoH links to ~21% higher odds of premature ASCVD, especially in women.
Why the study?
Premature ASCVD is a major public health issue with productivity losses and higher healthcare costs, and the association between SDoH and premature ASCVD with sex differences was unclear.
Do unfavorable social determinants of health increase the risk of premature ASCVD in US adults, and are there sex differences?
Cross-Sectional
Do unfavorable social determinants of health increase the risk of premature ASCVD in US adults, and are there sex differences?
Odds Ratio: 1.21 (95% CI 1.16–1.26)
p-value: p=<0.01
Cumulative unfavorable social determinants of health are significantly associated with an increased risk of premature ASCVD, with women exhibiting greater susceptibility than men.
May inform sex-specific ASCVD risk stratification incorporating social determinants; leaves open causality and intervention effects.
Background: Premature atherosclerotic cardiovascular disease (ASCVD) is a major public health issue, leading to productivity losses and higher healthcare costs. This study examines the association between social determinants of health (SDoH) and premature ASCVD, with a focus on sex differences. Method: Data on self-reported SDoH based on Healthy People 2030 criteria were obtained from U.S. National Health and Nutrition Examination Surveys (2003-2018). Weighted logistic regression models were used to examine the relationship between SDoH (including eight sub-items and the cumulative number of unfavorable SDoH) and premature ASCVD. Analyses were further stratified by sex. Result: = 972]), they exhibited a higher level of unfavorable SDoH compared to men. Logistic regression indicated a 21 % increase in risk for each additional unfavorable SDoH (AOR = 1.21; 95 % CI, 1.16-1.26), and the cumulative number of unfavorable SDoH were positively associated with the odds of developing premature ASCVD (P for trend <0.01). Notably, the impact of unfavorable SDoH was greater in women, revealing significant sex disparities in susceptibility to premature ASCVD. Conclusion: This study demonstrates that unfavorable SDoH significantly increase the risk of developing premature ASCVD. Furthermore, the cumulative effect of unfavorable SDoH pose a higher risk for women.
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Yang et al. (2025) conducted a cross-sectional in Premature atherosclerotic cardiovascular disease (ASCVD). Unfavorable social determinants of health (SDoH) vs. Fewer unfavorable SDoH was evaluated on Premature ASCVD (AOR 1.21, 95% CI 1.16-1.26, p=<0.01). Each additional unfavorable social determinant of health was associated with a 21% increased odds of premature ASCVD (AOR 1.21; 95% CI 1.16-1.26), with a greater impact observed in women.
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