Key result
Elevated NT-proBNP in COPD exacerbations is linked to biventricular dysfunction.
Why the study?
The pathophysiology underlying elevated NT-proBNP levels in patients with COPD exacerbations and their association with cardiac dysfunction is unclear.
Are elevated levels of NT-proBNP associated with right or left heart dysfunction in patients admitted with COPD exacerbations?
Observational (n=18)
Are elevated levels of NT-proBNP associated with right or left heart dysfunction in patients admitted with COPD exacerbations?
Elevated NT-proBNP in patients with COPD exacerbations reflects biventricular dysfunction rather than isolated right heart compromise.
Answers are grounded in this paper and cite their sources.
NT-proBNP elevation in COPD exacerbations signals biventricular dysfunction; hypothesis-generating for prognostic and management implications.
Elevated levels of B-type natriuretic peptides among patients with exacerbations of chronic obstructive pulmonary disease (COPD) are associated with higher mortality. The pathophysiology is unclear. To establish if elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) are due to right or left heart dysfunction, we performed echocardiograms in 18 patients admitted to hospital with COPD. Elevated levels of NT-proBNP were associated with both right and left heart dysfunction and indicate that these patients have biventricular dysfunction rather than isolated right ventricular compromise.
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Lee et al. (2013) conducted an observational in Exacerbations of chronic obstructive pulmonary disease (COPD) (n=18). Elevated levels of NT-proBNP was evaluated on Right or left heart dysfunction on echocardiogram. Elevated levels of NT-proBNP in patients admitted with COPD exacerbations were associated with both right and left heart dysfunction, indicating biventricular dysfunction.
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