Key result
Symptomatic carotid disease linked to ~1.9-fold higher perivascular adiponectin levels versus asymptomatic disease.
Why the study?
Recent symptoms are a major determinant of stroke risk in carotid stenosis and may reflect atherosclerotic plaque destabilization, with potential links to perivascular adipose biology.
Do perivascular adipose characteristics associate with carotid disease symptom status in patients undergoing carotid endarterectomy?
Observational (n=34)
Do perivascular adipose characteristics associate with carotid disease symptom status in patients undergoing carotid endarterectomy?
Symptomatic carotid disease is associated with higher perivascular adiponectin levels, suggesting a local paracrine relationship with vascular disease processes.
May reflect local adipose-vascular signaling but should not change practice; leaves open causal role in carotid plaque instability.
BACKGROUND AND PURPOSE: Recent symptoms stand as a major determinant of stroke risk in patients with carotid stenosis, likely reflective of atherosclerotic plaque destabilization. In view of emerging links between vascular and adipose biology, we hypothesized that human perivascular adipose characteristics associate with carotid disease symptom status. METHODS: Clinical history, carotid plaques, blood, and subcutaneous and perivascular adipose tissues were prospectively collected from patients undergoing carotid endarterectomy. Nine adipose-associated biological mediators were assayed and compared in patients with symptomatic (n=15) versus asymptomatic (n=19) disease. Bonferroni correction was performed for multiple testing (α/9=0.006). RESULTS: Symptomatic patients had 1.9-fold higher perivascular adiponectin levels (P=0.005). Other circulating, subcutaneous, and perivascular biomarkers, as well as microscopic plaque characteristics, did not differ between symptomatic and asymptomatic patients. CONCLUSIONS: Symptomatic and asymptomatic carotid endarterectomy patients display a tissue-specific difference in perivascular adipose adiponectin. This difference, which was not seen in plasma or subcutaneous compartments, supports a potential local paracrine relationship with vascular disease processes that may be related to stroke mechanisms.
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Sharma et al. (2015) conducted an observational in Carotid stenosis (n=34). Symptomatic carotid disease vs. Asymptomatic carotid disease was evaluated on Perivascular adipose adiponectin levels (1.9-fold higher, p=0.005). Symptomatic carotid disease was associated with 1.9-fold higher perivascular adiponectin levels compared to asymptomatic disease in patients undergoing carotid endarterectomy (P=0.005).
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