Cerium oxide nanoparticles protect primary osteoblasts against hydrogen peroxide induced oxidative damage

Oxidative damage is an important contributor to the morphological and the functional changes in the development of osteoporosis. In this reported work, the use of cerium oxide (CeO 2 ) nanoparticles as a potential therapeutic agent for osteoporosis is explored. By using the primary osteoblasts (OBs) exposed to hydrogen peroxide (H 2 O 2 ), it is shown that the CeO 2 nanoparticles relieve the H 2 O 2 ‐induced oxidative damage. The protective effects of the CeO 2 nanoparticles were because of a reduction in the reactive oxygen species (ROS). The level of the antioxidant enzymes was increased after treatment with the CeO 2 nanoparticles in the OBs exposed to H 2 O 2 . Moreover, the cell apoptosis rate was decreased after treatment with the CeO 2 nanoparticles. The CeO 2 nanoparticles protect the OBs against the H 2 O 2 ‐induced oxidative damage, suppression of the antioxidant enzymes depletion and cell apoptosis via its ROS scavenging mechanism. The findings suggest that the CeO 2 nanoparticles may have a potentially therapeutic value for the diseases related to the ROS.