What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Undervaccination (n=4726). Intervention: Poorest wealth quintile vs. Middle wealth quintile. Primary outcome: Undervaccination (OR 2.58, 95% CI 1.76-3.78).

What does this research mean for the field?

Children in the poorest wealth quintile in Pakistan have significantly higher odds of undervaccination compared to the middle quintile, with socioeconomic and provincial disparities persisting despite overall increases in childhood vaccination coverage. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 11, 2024VaccineOpen Access

Trends in childhood vaccination in Pakistan and associated factors; 2006–2018

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Key result

Lowest wealth quintile linked to ~158% higher odds of undervaccination versus the middle quintile.

OR 2.58
95% CI 1.76-3.78
n=4,726

Why the study?

Pakistan continues to have ongoing transmission of wild type polio virus, and changes in full vaccination coverage by socio-economic and demographic factors were not well characterized.

Comparison

Vaccination coverage by residence, wealth, and sociodemographic factors over time

Design

Population-based cross-sectional study using Demographic and Health Survey data

Authors

GJGrace E. JoachimMichigan State University AWAbram L. WagnerUniversity of Michigan MNMustafa NaseemUniversity of Michigan

Discussion

Member takes

Implication

May warrant targeted outreach for low-income groups; leaves open whether interventions reduce disparities in prospective trials.

Study Design

Type

Cross-Sectional (n=4,726)

Multicenter

Yes

Structured PICO

Population

4,726 children aged 12-23 months in Pakistan analyzed across three cross-sectional survey waves from 2006 to 2018 to determine factors associated with undervaccination.

Outcome

Full vaccination coverage (receipt of one Bacillus Calmette-Guérin dose, one measles dose, 3 polio doses, and 3 Diphtheria-Tetanus-Pertussis doses) and odds of undervaccination by demographic variables

Main Result

Odds Ratio: 2.58 (95% CI 1.76–3.78)

While overall childhood vaccination coverage in Pakistan has improved from 2006 to 2018, significant geographic and socioeconomic disparities in undervaccination persist.

Cite This Study

Joachim et al. (2024) conducted a cross-sectional in Undervaccination (n=4,726). Poorest wealth quintile vs. Middle wealth quintile was evaluated on Undervaccination (OR 2.58, 95% CI 1.76-3.78). Being in the poorest wealth quintile was associated with significantly higher odds of undervaccination compared to the middle quintile (OR 2.58; 95% CI 1.76-3.78).

synapsesocial.com/papers/6aabb2e726686b6c76d3b9f2 https://doi.org/10.1016/j.vaccine.2024.01.014

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January 11, 2024VaccineOpen Access

Trends in childhood vaccination in Pakistan and associated factors; 2006–2018

View Full Paper

Ask AI

Bookmark

Key result

Lowest wealth quintile linked to ~158% higher odds of undervaccination versus the middle quintile.

OR 2.58
95% CI 1.76-3.78
n=4,726

Why the study?

Pakistan continues to have ongoing transmission of wild type polio virus, and changes in full vaccination coverage by socio-economic and demographic factors were not well characterized.

Comparison

Vaccination coverage by residence, wealth, and sociodemographic factors over time

Design

Population-based cross-sectional study using Demographic and Health Survey data

Authors

GJGrace E. JoachimMichigan State University AWAbram L. WagnerUniversity of Michigan MNMustafa NaseemUniversity of Michigan

Discussion

Member takes

Implication

May warrant targeted outreach for low-income groups; leaves open whether interventions reduce disparities in prospective trials.

Study Design

Type

Cross-Sectional (n=4,726)

Multicenter

Yes

Structured PICO

Population

4,726 children aged 12-23 months in Pakistan analyzed across three cross-sectional survey waves from 2006 to 2018 to determine factors associated with undervaccination.

Outcome

Main Result

Odds Ratio: 2.58 (95% CI 1.76–3.78)

While overall childhood vaccination coverage in Pakistan has improved from 2006 to 2018, significant geographic and socioeconomic disparities in undervaccination persist.

Cite This Study

synapsesocial.com/papers/6aabb2e726686b6c76d3b9f2 https://doi.org/10.1016/j.vaccine.2024.01.014

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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