Key result
Induced delivery after azithromycin manages concurrent intrauterine arrhythmia and prevents neonatal pertussis.
Why the study?
Prenatal pertussis has reemerged as a concern, complicating management of fetal arrhythmia during pregnancy.
Case Report (n=1)
Careful perinatal management, including discontinuation of digoxin and initiation of azithromycin followed by induced delivery, can prevent neonatal pertussis infection in pregnancies complicated by fetal SVT.
Answers are grounded in this paper and cite their sources.
Pertussis testing may be warranted in pregnant patients with cough and fetal arrhythmia on digoxin; this Level 5 case leaves open any causal or pharmacokinetic interaction.
Prenatal pertussis has become a concern once again with the reappearance of the disease in the USA. A 30-year-old mother whose pregnancy was complicated with fetal arrhythmia was referred for further evaluation in the third trimester. After initial treatment with antiarrhythmic medications due to continued irregular rhythm, she was revisited for persistent hacking cough at 38 weeks gestational age. PCR examination confirmed pertussis diagnosis. Owing to increased risk of digoxin toxicity with concurrent antibiotic administration, antiarrhythmic medication was discontinued. Delivery was induced 2 days after the initiation of azithromycin therapy to prevent the transmission of the disease to the neonate. A well-planned delivery in a patient with prenatal diagnosis prevents neonatal infection while considering the obstetrical dilemma for concurrent management of the intrauterine arrhythmia and antibiotic administration.
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DeJong et al. (2015) conducted a case report in Fetal supraventricular tachycardia complicated by maternal pertussis (n=1). Azithromycin therapy and induced delivery was evaluated on Prevention of neonatal infection and management of intrauterine arrhythmia. Induced delivery following azithromycin therapy successfully prevented neonatal pertussis infection while managing the obstetrical dilemma of concurrent intrauterine arrhythmia and antibiotic use.
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