Inhibited TLR-4/NF- κB Pathway Mediated by Cannabinoid Receptor 2 Activation Curbs Ongoing Liver Fibrosis in Bile Duct Ligated Rats

Advances in Animal and Veterinary SciencesAs for example; hepatotropic viruses infections such as hepatitis B and C viruses (HCV), chronic exposition to various drugs or toxins such as alcohol abuse, cholestatic diseases and chronic autoimmune hepatitis (Hernández-Aquino et al., 2017).The mechanism triggering the occurrence of hepatic fibrosis is the imbalance between the deposition and the removal of extracellular matrix (ECM).The key fibrogenic cell in liver tissue is the hepatic stellate cells (HSCs), which are the dominant producers of ECM.