Key result
A 4-barrier, 3-site model simulates ion permeability ratios and voltage-dependent block in Shaker K channels.
Why the study?
The permeation properties and ion selectivity of the pore in Shaker K channels were investigated to better understand ion permeation mechanisms.
Population
Shaker K channels expressed with baculovirus/Sf9 expression system
Comparison
Permeability and block by varying external and internal K+, Rb+, NH4+, and Cs+ concentrations
Design
Whole-cell patch clamp electrophysiology study
Authors
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The model fits Shaker K channel data; leaves open relevance to native mammalian channels or clinical ion channel disorders.
A 4-barrier, 3-site permeation model can simulate the multi-ion permeation properties of Shaker K+ channels.
Pérez‐Cornejo et al. (1994) studied this question. External Rb+, NH4+, and Cs+ ions vs. Internal K+ was evaluated on Apparent permeability ratio and block of the pore. A 4-barrier, 3-site permeation model simulated the apparent permeability ratios of K+, Rb+, and NH4+ ions and the voltage-dependent block by external Cs+ ions in Shaker K channels.
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