From Phytochemistry to Skin Regeneration: Therapeutic Potential of Copaifera-Derived Bioactive Compounds for Wound Healing and Dermocosmetic Applications—A Systematic Review

Cutaneous wound healing is a complex biological process that remains challenging, particularly in chronic wounds requiring effective and safe therapeutic strategies. Copaifera species are rich sources of bioactive terpenoids with recognized pharmacological properties and increasing potential for dermocosmetic applications. This systematic review aimed to critically evaluate the phytochemical composition and wound-healing activities of Copaifera-derived products. The review followed the PRISMA 2020 guidelines and searched MEDLINE/PubMed, SciELO, PEDro, and Scopus. Studies published between 2015 and 2025 were screened, and 20 studies met the eligibility criteria for qualitative synthesis. The available evidence demonstrated that Copaifera-derived products, particularly oleoresins, exhibit anti-inflammatory, antioxidant, antimicrobial, antinociceptive, and regenerative activities that promote wound contraction, re-epithelialization, collagen deposition, and extracellular matrix remodeling. β-Caryophyllene was the most frequently identified phytochemical, followed by β-bisabolene, α-humulene, α-bergamotene, copalic acid, and kaurenoic acid. Recent investigations also indicated the incorporation of Copaifera bioactive compounds into biomaterials and nanotechnology-based delivery systems to increase topical therapeutic performance. Despite these promising findings, the current evidence remains predominantly preclinical and is limited by methodological heterogeneity and the scarcity of clinical trials. Overall, Copaifera represents a promising natural source for developing innovative wound-healing therapies and dermocosmetic formulations.