Key result
Clozapine use links to pericarditis with pericardial effusion that resolves completely upon drug discontinuation.
Why the study?
Clozapine is known to cause myocarditis and cardiomyopathy, but reports of clozapine-induced pericarditis and pericardial effusion are rare.
Comparison
Clozapine therapy vs clozapine discontinuation
Design
Case report
Follow-up
Several days
Authors
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May warrant cardiac monitoring with clozapine; hypothesis-generating case report requiring confirmation.
Case Report (n=1)
No
Clozapine can cause potentially life-threatening pericarditis and pericardial effusion, which may resolve upon discontinuation of the drug.
Markovic et al. (2011) conducted a case report in Psychotic disorder / Clozapine-induced pericarditis (n=1). Clozapine was evaluated on Development and resolution of pericardial effusion. Clozapine therapy was identified as the probable cause of pericarditis with pericardial effusion in a 21-year-old man, which resolved completely upon discontinuation of the drug.
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