What question did this study set out to answer?

Identify genome-wide significant susceptibility loci associated with cognitive restraint, uncontrolled eating, and emotional eating.

September 17, 2026Molecular PsychiatryOpen Access

Genome-wide association meta-analysis of eating behavior traits revealed one susceptibility locus for emotional eating

View Full Paper

Ask AI

Bookmark

Authors

MMManon Muntaner KHKatrin Horn BLBlandine de Lauzon‐Guillain

Discussion

Member takes

Overview

Genome-wide meta-analysis uncovers a chromosome 5 susceptibility locus linked to emotional eating in European individuals, highlighting a shared genetic architecture with obesity risk.

Key Points

Identify genome-wide significant susceptibility loci associated with cognitive restraint, uncontrolled eating, and emotional eating.
Conducted a fixed-effect meta-GWAS across 7 studies of European ancestry (N=11,250).
Assessed eating behaviors using the Three-Factor Eating Questionnaire (TFEQ) and modeled genotype effects with additive regressions adjusted for age, sex, BMI, and principal components.
Identified one genome-wide significant locus for emotional eating on chromosome 5 mapped to RP11-24P24.1 (rs6877636, P=4.0×10⁻⁸; rs6897090, P=3.2×10⁻⁸), with minor alleles increasing emotional eating scores (β=0.093 ± 0.017).
Detected no genome-wide significant loci for cognitive restraint or uncontrolled eating, though an FTO variant showed suggestive association with cognitive restraint (rs9922708, β=0.069, P=5.9×10⁻⁷).
Observed significant enrichment overlap between nominal emotional eating variants and genome-wide BMI-associated variants.

Cite This Study

Muntaner et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6445f706d05830e4a34 https://doi.org/10.1038/s41380-026-03889-6

View Full Paper

Ask AI

Bookmark

September 17, 2026Molecular PsychiatryOpen Access

Genome-wide association meta-analysis of eating behavior traits revealed one susceptibility locus for emotional eating

View Full Paper

Ask AI

Bookmark

Authors

MMManon Muntaner KHKatrin Horn BLBlandine de Lauzon‐Guillain

Discussion

Member takes

Overview

Genome-wide meta-analysis uncovers a chromosome 5 susceptibility locus linked to emotional eating in European individuals, highlighting a shared genetic architecture with obesity risk.

Key Points

Identify genome-wide significant susceptibility loci associated with cognitive restraint, uncontrolled eating, and emotional eating.
Conducted a fixed-effect meta-GWAS across 7 studies of European ancestry (N=11,250).
Assessed eating behaviors using the Three-Factor Eating Questionnaire (TFEQ) and modeled genotype effects with additive regressions adjusted for age, sex, BMI, and principal components.
Identified one genome-wide significant locus for emotional eating on chromosome 5 mapped to RP11-24P24.1 (rs6877636, P=4.0×10⁻⁸; rs6897090, P=3.2×10⁻⁸), with minor alleles increasing emotional eating scores (β=0.093 ± 0.017).
Detected no genome-wide significant loci for cognitive restraint or uncontrolled eating, though an FTO variant showed suggestive association with cognitive restraint (rs9922708, β=0.069, P=5.9×10⁻⁷).
Observed significant enrichment overlap between nominal emotional eating variants and genome-wide BMI-associated variants.

Cite This Study

Muntaner et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6445f706d05830e4a34 https://doi.org/10.1038/s41380-026-03889-6

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark