Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta‐analysis

Luca Coccoluto; Luca Antonelli; Ivana Crescenzi; Marco Crescenzi; Roberto Rotundo

doi:10.1111/prd.70087

September 15, 2026Periodontology 2000

Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta‐analysis

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Key Points

To assess the adjunctive clinical efficacy and indications of chlorhexidine mouthrinses on periodontal parameters and postoperative wound healing during nonsurgical and surgical periodontal treatment.
Systematic search of Medline, EMBASE, Cochrane Library, Scopus, and Web of Science following two PICOS frameworks for randomized controlled trials comparing adjunctive chlorhexidine to placebo or no rinse.
Conducted random-effects meta-analyses for nonsurgical outcomes and synthesized surgical outcomes qualitatively due to substantial heterogeneity, supported by GRADE assessments and sensitivity analyses across 20 trials.
In nonsurgical periodontal therapy, adjunctive chlorhexidine produced modest reductions in probing pocket depth (mean difference, -0.30 mm; 95% CI, -0.50 to -0.09) and bleeding on probing (mean difference, -9.35 percentage points; 95% CI, -14.17 to -4.53), but showed no meaningful benefit for clinical attachment level.
In surgical therapy, qualitative assessment demonstrated improved early postoperative plaque and inflammatory control, with no evidence of superior long-term wound healing.

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Implication

Systematic review and meta-analysis reveals modest anti-inflammatory benefits of adjunctive chlorhexidine in periodontal therapy, suggesting limited utility beyond early postoperative control.

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Coccoluto et al. (2026) studied this question.

synapsesocial.com/papers/6aabb68c5f706d05830e50fd https://doi.org/10.1111/prd.70087

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Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta‐analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta‐analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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