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September 17, 2026Journal of Leukocyte Biology

The light side of mast cell degranulation: delivering macrophage repair through molecular condensates

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Authors

ASAlejandro Schcolnik‐CabreraRCRommel Chacón‐Salinas

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Overview

Experimental study reveals mast cell condensates drive macrophage aggregation in sterile injury models, indicating a structured neuro-immune signaling axis for wound repair.

Key Points

  • To examine whether mast cell degranulation forms structured extracellular assemblies that direct localized macrophage behavior and promote tissue repair following sterile injury.
  • Assessed mast cell activation, granule dispersion, and macrophage aggregation in a sterile peritoneal injury model.
  • Investigated sensory neuron-driven substance P signaling, protein composition of condensates, and macrophage uptake via the scavenger receptor MARCO.
  • Visualized intercellular condensate transfer and F-actin-containing cytonemes using lattice light sheet microscopy.
  • Substance P from sensory nerves stimulated mast cells to release membraneless biomolecular condensates containing more than 200 proteins.
  • Condensates bound to large peritoneal macrophages via the MARCO scavenger receptor, stimulating cellular aggregation and a wound-repair phenotype.
  • F-actin cytonemes captured and distributed condensates across macrophages, whereas blocking this pathway impaired macrophage recruitment and tissue healing.

Cite This Study

Schcolnik‐Cabrera et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6b55f706d05830e54cbhttps://doi.org/10.1093/jleuko/qiag125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.2026
  2. 2Investigating the Role of Mast Cell Condensates in Regulating Macrophage Phenotype and Dynamics in Tissue Repair 23091912026
  3. 3Emerging Role of Mast Cells as Biological Markers in the Pathogenesis of Infectious Diseases and their Projection in Health Emergencies2024
  4. 4Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine2026 · 1 citations
  5. 5Mast cell activation and degranulation in acute artery injury: A target for post‐operative therapy2023 · 6 citations