6‐tert‐Butyldimethylsilyl‐2,3‐dimethyl‐α‐, β‐, and γ‐cyclodextrins, dissolved in polysiloxanes, as chiral selectors for gas chromatography. Influence of selector concentration and polysiloxane matrix polarity on enantioselectivity

The enantioselectivity of three chiral selectors, 6‐t‐butyldimethyl‐silyl‐2,3‐dimethyl‐α‐, β‐ and γ‐cyclodextrin (TB‐α‐CD, TB‐β‐CD, TB‐γ‐CD), are compared and discussed for a range of chiral test compounds. TB‐β‐CD in particular offers high enantioselectivity for a variety of chiral compounds and has the special property of excellent solubility in different alkylpolysiloxanes, including the weakly polar variety, because of its weak self‐association. To investigate the influence of the polarity of polysiloxane matrices this selector can be used at a wide range of concentrations in the most suitable polysiloxane matrices and at low separation temperatures without impairment of resolution by peak broadening and symmetry distortion.