Narrative review demonstrates the therapeutic potential of herbal nanoformulations in vitiligo, highlighting improved skin permeation and targeted melanogenesis stimulation.
Key Points
To evaluate the pathophysiological mechanisms, formulation strategies, characterization parameters, and therapeutic potential of herbal drug-loaded nanoparticles for vitiligo management.
Reviewed the multifactorial pathogenesis of vitiligo, focusing on oxidative stress, autoimmune destruction, inflammatory signaling, and melanocyte apoptosis.
Analyzed nanoparticle drug delivery platforms designed to overcome the low aqueous solubility, poor stability, and limited cutaneous penetration of herbal bioactives.
Identified that conventional interventions, including phototherapy and corticosteroids, demonstrate limited long-term efficacy due to high recurrence rates and adverse effects.
Synthesized findings showing that nanoformulations markedly improve herbal compound bioavailability, deepen skin penetration, and provide sustained release to stimulate melanogenesis.