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September 17, 2026Future Medicinal Chemistry

Exploring the antidiabetic potential of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazole hybrids: synthesis, α-glucosidase inhibition and molecular modeling studies

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Authors

AGAnshul GroverVAVivek AsatiJSJayant Sindhu

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Overview

In vitro study reveals potent alpha-glucosidase inhibition by a chalcone-triazole hybrid, suggesting a promising lead compound for diabetes management.

Key Points

  • Synthesize novel DHA-salicylaldehyde-chalcone endowed 1,2,3-triazole hybrids and evaluate their potential as α-glucosidase inhibitors to counter diabetes mellitus.
  • Synthesized a library of twelve DHA-salicylaldehyde-chalcone 1,2,3-triazole hybrids (4a–4l) and confirmed their chemical structures using FTIR, NMR, and HRMS spectroscopy.
  • Assayed all synthetic hybrids for in vitro α-glucosidase inhibitory activity and performed in silico molecular docking simulations to assess ligand-protein binding interactions.
  • Identified hybrid 4k as the most potent α-glucosidase inhibitor with an IC50 of 1.35 µM, demonstrating a tenfold greater potency than the reference drug acarbose (IC50 = 13.5 µM).
  • Molecular docking investigations confirmed favorable binding interactions between hybrid 4k and the active site of the α-glucosidase enzyme.

Cite This Study

Grover et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6d85f706d05830e57c2https://doi.org/10.1080/17568919.2026.2732256
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