PKCδ and pharmacomechanical control of cerebral arterial tone

Muhammad Talha

doi:10.1113/jp292343

September 14, 2026The Journal of PhysiologyOpen Access

PKCδ and pharmacomechanical control of cerebral arterial tone

View Full Paper

Ask AI

Bookmark

Share

Key Points

To examine how pharmacomechanical coupling and PKCδ signaling regulate spatial arterial tone and localized blood distribution in cerebral resistance vessels.
Evaluation of electromechanical versus pharmacomechanical coupling mechanisms in vascular smooth muscle cells.
Analysis of downstream calcium sensitization cascades involving PKC-dependent CPI-17 phosphorylation and RhoA/Rho-kinase MYPT1 phosphorylation.
Arterial smooth muscle contracts via electromechanical coupling driven by membrane depolarization and pharmacomechanical coupling mediated by myosin light chain phosphatase inhibition.
Pharmacomechanical signaling enables localized calcium sensitization and vascular tone adjustment independently of widespread membrane potential shifts, facilitating spatially heterogeneous perfusion.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Mechanistic analysis reveals how pharmacomechanical coupling governs localized tone in cerebral resistance arteries, highlighting pathways that regulate regional brain perfusion.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Muhammad Talha (2026) studied this question.

synapsesocial.com/papers/6aabb6e95f706d05830e5b2e https://doi.org/10.1113/jp292343

View Full Paper

Ask AI

Bookmark

Share

PKCδ and pharmacomechanical control of cerebral arterial tone

Key Points

No abstract yet

Implication

Discussion

Cite This Study

PKCδ and pharmacomechanical control of cerebral arterial tone

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading