What question did this study set out to answer?

This study aims to explore how protein kinase C (PKC) affects myogenic tone in cerebral resistance arteries.

February 1, 1991Circulation ResearchOpen Access

Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation.

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Randomized trial demonstrates that protein kinase C modifies myogenic tone in resistance arteries, suggesting new regulatory pathways.

This study aims to explore how protein kinase C (PKC) affects myogenic tone in cerebral resistance arteries.
Pial arteries isolated from Wistar-Kyoto rats were analyzed using an arteriograph.
Transmural pressure and lumen diameter were simultaneously recorded with a video-electronic system.
Experiments involved PKC modulation through staurosporine inhibition and indolactam activation.
Staurosporine caused progressive dilation, with half-maximal inhibition of myogenic tone at 1.32 nM concentration.
Indolactam reduced diameter by 62% and had half-maximal effects at 0.4 microM.
PKC modulation did not change diameter responses to acute transmural pressure increases.

Osol et al. (1991) studied this question.

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