Population
Human small resistance arteries from the subcutaneous vascular bed
Comparison
Pharmacological modulators including Ca… vs Control
Design
Preclinical
Authors
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May inform antihypertensive target discovery; leaves open clinical translation in hypertension.
The generation of pressure-dependent myogenic tone in human subcutaneous arteries is dependent on Ca(2+) influx via voltage-operated Ca(2+) channels and the activation of phospholipase C, diacylglycerol, and protein kinase C.
Paul Coats (2001) studied this question.
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