Population
in vitro perfused hydronephrotic rat kidney model
Comparison
Protein kinase C inhibition and activation vs Basal conditions
Design
Preclinical
Authors
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Does not support PKC-targeted therapies in hypertension; hypothesis-generating for Kv channel modulation in renal autoregulation.
Basal PKC activity indirectly modulates myogenic reactivity in the renal afferent arteriole by affecting voltage-gated K channel activity, rather than playing a direct obligate role in myogenic signaling.
Kirton et al. (1998) studied this question.
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