What question did this study set out to answer?

To investigate the influence of tube voltage on virtual monoenergetic image CT values and contrast-to-noise ratios across various phantom sizes, keV levels, and clinical settings in photon-counting detector CT.

September 17, 2026Investigative RadiologyOpen Access

Influence of X-ray Tube Voltage on Computed Tomography Values and Contrast-Noise Ratios in Virtual Monoenergetic Images in routine clinical Photon Counting Detector Computed Tomography

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Authors

CJCécile R. L. P. N. Jeukens FPFlorentina M.E. Pinckaers BMBibi Martens

Discussion

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Overview

Phantom and retrospective cohort study demonstrates stable CT values across tube voltages in photon-counting CT, highlighting enhanced dose efficiency at lower voltages.

Key Points

To investigate the influence of tube voltage on virtual monoenergetic image CT values and contrast-to-noise ratios across various phantom sizes, keV levels, and clinical settings in photon-counting detector CT.
Scanned an abdominal phantom with iodine (2–15 mg/mL), calcium, and tissue inserts at 70, 90, 120, and 140 kV on a photon-counting detector CT across three phantom sizes.
Reconstructed virtual monoenergetic images (40–100 keV) to calculate the percentage CT deviation (ΔCT) across tube voltages and radiation dose-normalized contrast-to-noise ratio (CNRD).
Retrospectively analyzed 67 cerebral CT angiography patients scanned at 140 kV (n = 42) or 90 kV (n = 25) with 55 keV virtual monoenergetic images.
Iodine and calcium CT values remained stable within a predefined 10% tolerance across all tube voltages at 40 to 70 keV (ΔCT ≤ 8.4%), though ΔCT reached 36% (19 HU deviation) at 100 keV for 5 mg/mL iodine.
Adipose and liver tissues maintained ΔCT ≤ 10% from 45 to 70 keV, and dose-normalized CNR was 10% to 13% higher at 70 and 90 kV compared to 120 and 140 kV in small phantoms at 40 to 60 keV.
In patient cerebral CT angiographies at 55 keV, dose-normalized CNR was 17% to 29% higher at 90 kV than at 140 kV, though the differences were not statistically significant.

Cite This Study

Jeukens et al. (2026) studied this question.

synapsesocial.com/papers/6aabb73d5f706d05830e6205 https://doi.org/10.1097/rli.0000000000001312

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September 17, 2026Investigative RadiologyOpen Access

Influence of X-ray Tube Voltage on Computed Tomography Values and Contrast-Noise Ratios in Virtual Monoenergetic Images in routine clinical Photon Counting Detector Computed Tomography

View Full Paper

Ask AI

Bookmark

Authors

CJCécile R. L. P. N. Jeukens FPFlorentina M.E. Pinckaers BMBibi Martens

Discussion

Member takes

Overview

Phantom and retrospective cohort study demonstrates stable CT values across tube voltages in photon-counting CT, highlighting enhanced dose efficiency at lower voltages.

Key Points

To investigate the influence of tube voltage on virtual monoenergetic image CT values and contrast-to-noise ratios across various phantom sizes, keV levels, and clinical settings in photon-counting detector CT.
Scanned an abdominal phantom with iodine (2–15 mg/mL), calcium, and tissue inserts at 70, 90, 120, and 140 kV on a photon-counting detector CT across three phantom sizes.
Reconstructed virtual monoenergetic images (40–100 keV) to calculate the percentage CT deviation (ΔCT) across tube voltages and radiation dose-normalized contrast-to-noise ratio (CNRD).
Retrospectively analyzed 67 cerebral CT angiography patients scanned at 140 kV (n = 42) or 90 kV (n = 25) with 55 keV virtual monoenergetic images.
Iodine and calcium CT values remained stable within a predefined 10% tolerance across all tube voltages at 40 to 70 keV (ΔCT ≤ 8.4%), though ΔCT reached 36% (19 HU deviation) at 100 keV for 5 mg/mL iodine.
Adipose and liver tissues maintained ΔCT ≤ 10% from 45 to 70 keV, and dose-normalized CNR was 10% to 13% higher at 70 and 90 kV compared to 120 and 140 kV in small phantoms at 40 to 60 keV.
In patient cerebral CT angiographies at 55 keV, dose-normalized CNR was 17% to 29% higher at 90 kV than at 140 kV, though the differences were not statistically significant.

Cite This Study

Jeukens et al. (2026) studied this question.

synapsesocial.com/papers/6aabb73d5f706d05830e6205 https://doi.org/10.1097/rli.0000000000001312

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