What question did this study set out to answer?

To develop a multifunctional, brain-penetrating nanoplatform that improves tumor boron delivery, provides real-time imaging, and reprograms the immunosuppressive tumor microenvironment for boron neutron capture therapy in glioma.

September 17, 2026Smart MoleculesOpen Access

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

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Authors

YLYiming LiuMacau University of Science and Technology XWXuejian WangWeifang Medical University BLBangjian LiDalian University

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Implication

Preclinical study demonstrates targeted boron delivery and immune activation in glioma-bearing mice, highlighting a theranostic platform for enhanced neutron capture therapy.

Key Points

To develop a multifunctional, brain-penetrating nanoplatform that improves tumor boron delivery, provides real-time imaging, and reprograms the immunosuppressive tumor microenvironment for boron neutron capture therapy in glioma.
Engineered an Angiopep-2-functionalized, boron-embedded covalent organic framework nanoplatform (DM&Ce6@COF-Ang) carrying the STING agonist DMXAA and the fluorescent imaging dye chlorin e6 (Ce6).
Assessed blood-brain barrier transcytosis via lipoprotein receptor-related protein 1 (LRP-1) targeting, biodistribution tracking, and tumor boron accumulation in orthotopic glioma-bearing mice compared with standard L-4-boronophenylalanine (BPA).
DM@COF-Ang accumulated selectively in orthotopic glioma, delivering a tumor boron concentration of 11.3 ± 2.9 ppm (tumor-to-normal ratio ≈ 4.0), significantly exceeding BPA at 1.9–3.8 ppm (tumor-to-normal ratio ≈ 2.0).
Selective delivery of DMXAA triggered STING pathway activation to reverse the immunosuppressive tumor microenvironment, while integrated Ce6 facilitated precise real-time fluorescence biodistribution monitoring.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6aabb73d5f706d05830e628d https://doi.org/10.1002/smo2.70107

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Implication

Preclinical study demonstrates targeted boron delivery and immune activation in glioma-bearing mice, highlighting a theranostic platform for enhanced neutron capture therapy.

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Discussion

Member takes

Implication

Key Points

Cite This Study

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Discussion

Member takes

Implication

Key Points

Cite This Study

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