What question did this study set out to answer?

To alert readers to unresolved data integrity concerns regarding figure validity in a 2006 publication on small interfering RNA targeting heat-shock protein 27.

September 17, 2026BJU International

EXPRESSION OF CONCERN : Small Interference RNA Targeting Heat‐Shock Protein 27 Inhibits the Growth of Prostatic Cell Lines and Induces Apoptosis via Caspase‐3 Activation In Vitro

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Overview

Editorial investigation reveals duplicated figure panels and mismatched experimental sequences in prostatic cell line models, highlighting compromised data integrity.

Key Points

To alert readers to unresolved data integrity concerns regarding figure validity in a 2006 publication on small interfering RNA targeting heat-shock protein 27.
Third-party allegations prompted an independent editorial investigation by the journal and publisher.
Inquiry evaluated Western blot images published in Figure 2 against prior publications by the authors.
The authors' institution was contacted to address the discrepancy, but provided no response.
Blots in Figure 2 were determined to originate from earlier publications and involved different siRNA sequences than reported.
Figure 2 does not represent the stated experimental conditions, rendering the published data invalid despite a prior correction.
An official Expression of Concern was issued by the journal due to the lack of institutional resolution.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6aabb7a65f706d05830e6df2 https://doi.org/10.1111/bju.70458

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September 17, 2026BJU International

EXPRESSION OF CONCERN : Small Interference RNA Targeting Heat‐Shock Protein 27 Inhibits the Growth of Prostatic Cell Lines and Induces Apoptosis via Caspase‐3 Activation In Vitro

View Full Paper

Ask AI

Bookmark

Discussion

Member takes

Overview

Editorial investigation reveals duplicated figure panels and mismatched experimental sequences in prostatic cell line models, highlighting compromised data integrity.

Key Points

To alert readers to unresolved data integrity concerns regarding figure validity in a 2006 publication on small interfering RNA targeting heat-shock protein 27.
Third-party allegations prompted an independent editorial investigation by the journal and publisher.
Inquiry evaluated Western blot images published in Figure 2 against prior publications by the authors.
The authors' institution was contacted to address the discrepancy, but provided no response.
Blots in Figure 2 were determined to originate from earlier publications and involved different siRNA sequences than reported.
Figure 2 does not represent the stated experimental conditions, rendering the published data invalid despite a prior correction.
An official Expression of Concern was issued by the journal due to the lack of institutional resolution.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6aabb7a65f706d05830e6df2 https://doi.org/10.1111/bju.70458

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