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September 17, 2026npj Breast CancerOpen Access

Progesterone reshapes the tumor immune microenvironment toward macrophage-driven immune suppression in hormone receptor–positive breast cancer

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Authors

ECEilidh I ChowanecHFHalyna FedosyukJTJulio C. Tinoco

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Cite This Study

Chowanec et al. (2026) studied this question.

synapsesocial.com/papers/6aabb7e75f706d05830e7302https://doi.org/10.1038/s41523-026-01047-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2091: Progesterone promotes immunosuppression in murine mammary tumors by modulating CD4 T cell viability and helper functions, promoting T cell apoptosis and a shift from inflammatory to anti-inflammatory cytokine profiles.2026
  2. 2Abstract 3971: Progesterone impacts regulatory T cell activity to promote immunosuppression in the mammary gland2024
  3. 3Abstract 6877: Progesterone promotes immunosuppression in the murine mammary gland by causing T cell death2024
  4. 4Abstract 2284: Progesterone receptor modulates the antigen processing and presentation machinery: Decreasing MHC class I expression on tumor2026
  5. 5Abstract 5364: Progesterone receptor modulates the antigen processing and presentation machinery decreasing MHC class I expression on tumors2024