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September 17, 2026General PsychiatryOpen Access

Towards precision medicine: Application of the structural causal model in psychiatry

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Authors

WCWei ChenLSLiya SunFZFanyuan Zhang

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Overview

Methodological review demonstrates the utility of structural causal models in psychiatric research, highlighting their potential to advance precision medicine.

Key Points

  • To outline the core capabilities of structural causal models as next-generation artificial intelligence tools and encourage their application in psychiatric precision medicine.
  • Reviewed foundational principles of structural causal models (SCMs), including causal graph identification, mechanism-based forecasting, and counterfactual reasoning.
  • Assessed practical applications, advantages, methodological limitations, and current adoption rates of SCM frameworks within psychiatric research.
  • SCM frameworks enable transparent visualization of causal graphs, individual-level inference, and virtual intervention experiments without requiring direct clinical exposure.
  • Current deployment in psychiatric literature remains sparse despite the methodology's capacity to surpass standard associational predictive models in guiding targeted treatments.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6aabb7f75f706d05830e759chttps://doi.org/10.1002/gps3.70053
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