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September 17, 2026JAMA Cardiology

Coronary Computed Tomography Angiography and Plaque Analysis for Screening

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Authors

AZAlexander R. ZheutlinJSJared A. SpitzJWJohn Wilkins

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Overview

Clinical viewpoint examines coronary computed tomography plaque analysis in asymptomatic adults, highlighting unproven clinical utility for routine screening.

Key Points

  • To evaluate whether current clinical evidence supports using quantitative coronary computed tomography angiography (CCTA) plaque analysis as a screening tool to guide therapy in asymptomatic adults.
  • Examined clinical literature and evidence regarding quantitative plaque characterization using coronary computed tomography angiography (CCTA).
  • Assessed the value and efficacy of applying CCTA plaque metrics to guide preventive medical therapy in asymptomatic adult populations.
  • Current clinical evidence does not support the routine implementation of quantitative CCTA plaque analysis as a screening strategy in asymptomatic adults.
  • Evidence demonstrating that plaque-guided treatment strategies improve long-term clinical outcomes compared with standard risk assessment models remains lacking.

Cite This Study

Zheutlin et al. (2026) studied this question.

synapsesocial.com/papers/6aabb8375f706d05830e7e5dhttps://doi.org/10.1001/jamacardio.2026.3823
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