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September 17, 2026AJP Cell Physiology

Somatostatin and its type 2 receptor expression in the pregnant and labouring myometrium

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Authors

OSOksana ShynlovaABAdam Boros-RauschABAnuradha Baishnob

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Overview

Preclinical laboratory study reveals increased somatostatin receptor 2 expression during term and preterm labour in pregnant myometrium, suggesting a functional role in uterine contractions.

Key Points

  • To determine whether somatostatin and its type 2 receptor regulate uterine contractility during term and preterm labour.
  • Evaluated somatostatin and receptor 2 expression via immunohistochemistry in uterine tissues from pregnant and labouring humans undergoing cesarean delivery and rodents (rats and mice, N=4–7/group).
  • Subjected cultured primary human myometrial cells to static mechanical stretch in vitro and analyzed protein expression by immunoblotting alongside somatostatin secretion using ELISA.
  • Assessed functional contraction in vitro by treating primary human myocytes embedded in collagen gels with exogenous somatostatin.
  • Immunohistochemistry demonstrated elevated receptor 2 protein levels in uterine myocytes and tissue macrophages during both term and preterm labour compared to non-labouring human and rodent tissues.
  • Mechanical stretch induced upregulation of receptor 2 in cultured human myocytes, and cell-conditioned media confirmed myocytes serve as a source of secreted somatostatin.
  • Exogenous somatostatin directly promoted collagen gel contraction mediated by primary human myocytes.

Cite This Study

Shynlova et al. (2026) studied this question.

synapsesocial.com/papers/6aabb8495f706d05830e7f69https://doi.org/10.1152/ajpcell.00050.2026
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