Key result
Higher uric acid/albumin ratio linked to ~14-fold greater odds of poor coronary collaterals in CTO.
Why the study?
Serum uric acid/albumin ratio (UAR) has emerged as a novel marker associated with poor cardiovascular outcomes, but its association with poor coronary collateral circulation in CTO patients was unclear.
Is the serum uric acid/albumin ratio associated with poor coronary collateral circulation in patients with chronic total occluded coronary arteries?
Cross-Sectional (n=212)
Is the serum uric acid/albumin ratio associated with poor coronary collateral circulation in patients with chronic total occluded coronary arteries?
Odds Ratio: 13.68 (95% CI 4.784–46.23)
p-value: p=<0.001
The serum uric acid/albumin ratio is an independent predictor of poor coronary collateral circulation in patients with chronic total occlusions, offering better discrimination than either marker alone.
UAR may mark poor CCC in CTO; hypothesis-generating, needs prospective validation before clinical use.
Introduction: Coronary collateral circulation (CCC) develops in chronic total occluded (CTO) vessels and protects the myocardium against ischemia in addition to the improvement of cardiac functions. Poor CCC is related to adverse cardiac events as well as poor prognosis. Serum uric acid/albumin ratio (UAR) has emerged as a novel marker associated with poor cardiovascular outcomes. We aimed to investigate whether there was an association between UAR and poor CCC in CTO patients. Methods: This study was comprised of 212 patients with CTO (92 with poor CCC and 120 with good CCC). All patients were graded based on Rentrop scores to poor CCC (Rentrop scores 0 and 1) and good CCC (Rentrop scores 2 and 3). Results: Poor CCC patients had higher frequencies of diabetes mellitus, triglyceride levels, Syntax and Gensini scores, uric acid, and UAR and lower lymphocyte, high-density lipoprotein cholesterol, and ejection fraction when compared to good CCC patients. UAR was an independent predictor of poor CCC in CTO patients. Furthermore, UAR had a better discriminative ability for patients with poor CCC from good CCC compared to serum uric acid and albumin. Conclusion: Based on the results of the study, the UAR could be used to detect poor CCC in CTO patients.
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Şaylık et al. (2023) conducted a cross-sectional in Chronic total occluded coronary arteries (CTO) (n=212). Serum uric acid/albumin ratio (UAR) was evaluated on Poor coronary collateral circulation (Rentrop scores 0 and 1) (OR 13.680, 95% CI 4.784-46.230, p=<0.001). A higher serum uric acid/albumin ratio was an independent predictor of poor coronary collateral circulation in patients with chronic total occlusion (OR 13.680).