Key result
Angelica acutiloba extract lowers SBP, hypothalamic ACE activity, glucose, and insulin in hypertensive rats.
Why the study?
Angelica acutiloba is used in Chinese herbal medicine and its effects on hypertension and insulin resistance in metabolic syndrome-associated disorders were examined in high-fat diet-fed spontaneously hypertensive rats.
Does Angelica acutiloba extract reduce hypertension and improve insulin resistance in spontaneously hypertensive rats fed a high-fat diet?
Does Angelica acutiloba extract reduce hypertension and improve insulin resistance in spontaneously hypertensive rats fed a high-fat diet?
Angelica acutiloba extract demonstrates antihypertensive and insulin-sensitizing effects in a hypertensive rat model fed a high-fat diet, potentially mediated by reduced brain ACE activity and inflammation.
AAE may mitigate HFD-induced hypertension and insulin resistance in SHRs; leaves open translation to human metabolic syndrome.
INTRODUCTION: Angelica acutiloba is one of the crude drugs used in Chinese herbal medicine, and its intake is expected to improve metabolic syndrome-associated disorders. Here, we examined the effects of A. acutiloba extract (AAE) on hypertension and insulin resistance induced by the treatment of high-fat diet (HFD) to spontaneously hypertensive rats (SHRs). Then, we investigated the mechanisms associated with the effects of AAE. METHODS: AAE was administered to HFD-fed SHRs. Systolic blood pressure (SBP), sympathetic nerve activity, hypothalamic angiotensin-converting enzyme (ACE) activity, blood glucose level, plasma insulin concentration, visceral fat mass, and gene expression of tumor necrosis factor-alpha (TNF-α) in the visceral fat were evaluated. RESULTS: AAE reduced the increases in SBP and hypothalamic ACE activity observed in the HFD-fed SHRs, whereas the suppressive effect on sympathetic nerve activity was slight. Environmental stress-induced pressure and sympathetic overactivity were suppressed by the treatment of AAE. It also decreased the increase in the blood glucose level, plasma insulin concentration, homeostasis model assessment for the insulin resistance, and TNF-α gene expression in the visceral fat, but not the increase in the visceral fat mass. CONCLUSION: AAE has an antihypertensive effect, suppresses stress-induced hypertension, and improves insulin resistance in HFD-fed SHRs. The suppression of brain ACE activity, sympathetic nerve activity, and inflammation are partly involved in the effects of AAE.
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Watanabe et al. (2022) studied Hypertension and insulin resistance. Angelica acutiloba extract (AAE) was evaluated on Systolic blood pressure, sympathetic nerve activity, hypothalamic ACE activity, blood glucose level, plasma insulin concentration, visceral fat mass, and TNF-α gene expression. Angelica acutiloba extract reduced systolic blood pressure, hypothalamic ACE activity, blood glucose, and plasma insulin in high-fat diet-fed spontaneously hypertensive rats.
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