Key result
CAC genetically correlates with LDL cholesterol and CIMT with waist circumference.
Why the study?
The study aimed to characterize associations among coronary artery disease risk factors, coronary artery calcification quantity, and carotid artery intima-media thickness and to estimate shared genetic and environmental contributions to both measures in asymptomatic adults.
Population
478 asymptomatic Amish adults in Lancaster County, Pennsylvania
Comparison
Associations among CAC quantity, CIMT, and traditional CAD risk factors
Design
Observational study from 2000-2006
Authors
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Supports distinct genetic influences on CAC versus CIMT; leaves open targeted prevention strategies pending validation.
Observational (n=478)
Different sets of genes appear to influence variation in coronary artery calcification (shared with LDL cholesterol) versus carotid intima-media thickness (shared with waist circumference).
Rampersaud et al. (2008) conducted an observational in Subclinical vascular disease (n=478). Coronary artery disease risk factors was evaluated on Heritability and genetic correlations of coronary artery calcification (CAC) quantity and carotid intima-media thickness (CIMT). Coronary artery calcification was genetically correlated with LDL cholesterol (0.55; P=0.005), whereas carotid intima-media thickness was genetically correlated with waist circumference (0.58; P=0.046).
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