Why the study?
Is carotid artery intima-media thickness increased in subjects with homozygous or heterozygous homocystinuria compared to healthy controls?
Is carotid artery intima-media thickness increased in subjects with homozygous or heterozygous homocystinuria compared to healthy controls?
Homozygous homocystinuria, but not heterozygous disease, is associated with common carotid wall hypertrophy, suggesting a role for severe hyperhomocysteinemia in early atherogenesis.
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Homozygous homocystinuria may promote early carotid hypertrophy; leaves open whether milder hyperhomocysteinemia affects atherogenesis risk.
Mégnien et al. (1998) studied this question.