April 1, 1993Circulation
Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.
Key result
Top quintile plasma homocyst(e)ine levels (>10.5 mumol/L) were associated with significantly higher odds of thickened carotid artery walls compared to the bottom quintile (OR 3.15; p<0.001).
Why the study?
Does elevated plasma homocyst(e)ine associate with thickened intimal-medial carotid walls in asymptomatic adults?
Population
287 pairs of asymptomatic adults with no history of atherosclerotic disease, selected from a probability…
Comparison
High plasma homocystine levels vs Low plasma homocystine levels
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Association does not warrant homocyst(e)ine testing in asymptomatic adults; leaves open its role as a research biomarker for subclinical atherosclerosis.
Study Design
Type
Case-Control (n=574)
Multicenter
Yes
Structured PICO
Does elevated plasma homocyst(e)ine associate with thickened intimal-medial carotid walls in asymptomatic adults?
P
Population
287 pairs of asymptomatic adults (men and women between 45 and 64 years old) with no history of atherosclerotic disease, selected from a probability sample of 15,800.
I
Intervention
High plasma homocyst(e)ine levels (top quintile > 10.5 mumol/L)
C
Comparator
Low plasma homocyst(e)ine levels (bottom quintile < 5.88 mumol/L)
O
Outcome
Thickened intimal-medial carotid wall as measured by B-mode ultrasoundsurrogate
Main Result
Effect estimate: OR 3.15
p-value: p=<0.001
Elevated plasma homocyst(e)ine levels are strongly associated with increased carotid intimal-medial thickness in asymptomatic adults without a history of atherosclerotic disease.
Cite This Study
Malinow et al. (1993) conducted a case-control in Asymptomatic adults (n=574). Elevated plasma homocyst(e)ine vs. Lower plasma homocyst(e)ine was evaluated on Thickened intimal-medial carotid wall (OR 3.15, p=<0.001). Top quintile plasma homocyst(e)ine levels (>10.5 mumol/L) were associated with significantly higher odds of thickened carotid artery walls compared to the bottom quintile (OR 3.15; p<0.001).