February 2, 1995New England Journal of Medicine
Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis
Why the study?
Are high plasma homocysteine concentrations associated with an increased risk of extracranial carotid-artery stenosis in elderly subjects?
Population
1041 elderly subjects (418 men and 623 women; age range, 67 to 96 years) from the Framingham Heart Study.
Comparison
Highest plasma homocysteine concentrations vs Lowest plasma homocysteine concentrations
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
High homocysteine was associated with carotid stenosis in the elderly; hypothesis-generating for B-vitamin intervention trials.
Structured PICO
Are high plasma homocysteine concentrations associated with an increased risk of extracranial carotid-artery stenosis in elderly subjects?
P
Population
1041 elderly subjects (418 men and 623 women; age range, 67 to 96 years) from the Framingham Heart Study.
I
Intervention
Highest plasma homocysteine concentrations (>= 14.4 mumol per liter)
C
Comparator
Lowest plasma homocysteine concentrations (<= 9.1 mumol per liter)
O
Outcome
Maximal degree of stenosis of the extracranial carotid arteries (stenosis of >= 25 percent) assessed by ultrasonographysurrogate
High plasma homocysteine concentrations and low concentrations of folate and vitamin B6 are associated with an increased risk of extracranial carotid-artery stenosis in the elderly.
Cite This Study
Selhub et al. (1995) studied this question.