Key result
Food before digoxin lowers peak plasma concentration ~33% without altering overall absorption.
Why the study?
The influence of food on the absorption of digoxin in normal subjects was unclear.
Does food ingestion affect the absorption of digoxin in healthy volunteers?
Does food ingestion affect the absorption of digoxin in healthy volunteers?
Absolute Event Rate: 2.8% vs 4.2%
p-value: p=<0.05
Food ingestion decreases the rate but not the extent of digoxin absorption.
Food slows digoxin absorption rate without altering extent in volunteers; leaves open relevance for patient dosing or monitoring.
The influence of food on absorption of digoxin was studied in 6 healthy volunteers who received 1.0 mg digoxin as 4 tablets of Lanoxin either after an overnight fast, immediately after a standard breakfast, or 90 min after a standard breakfast. There was no significant difference between the three regimens in terms of area under the plasma concentration-time curve for 79 hr or in the 10-day cumulative urinary excretion. The mean peak plasma concentration was higher (p less than 0.05) when digoxin was given fasting (4.2 +/- 0.46 ng/ml) than immediately after food (2.8 +/- 0.24 ng/ml). The mean peak plasma concentration when digoxin was administered 90 min after food (3.3 +/- 0.30 ng/ml) was intermediate but not significantly different from either of the other mean peak concentrations. The results demonstrate that ingestion of food decreases rate but not extent of absorption of concurrently administered digoxin.
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Johnson et al. (1978) studied Healthy volunteers (n=6). Digoxin immediately or 90 min after a standard breakfast vs. Digoxin after an overnight fast was evaluated on Mean peak plasma concentration (p=<0.05). Ingestion of food immediately before 1.0 mg digoxin decreased the mean peak plasma concentration compared to fasting (2.8 vs 4.2 ng/ml; p<0.05) but did not change the overall extent of absorption.
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