Why the study?
Does complete bed rest compared to normal daily activity affect steady-state serum digoxin concentration in elderly digoxin-treated outpatients?
Population
10 digoxin-treated outpatients (61-81 years of age)
Comparison
Complete bed rest for 10 hours after ingestion… vs Normal daily activity
Design
Other
Follow-up
24 hours
Authors
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Supports flexible pre-sampling activity for digoxin monitoring in elderly outpatients; leaves open confirmation in larger studies.
Does complete bed rest compared to normal daily activity affect steady-state serum digoxin concentration in elderly digoxin-treated outpatients?
Standardization of physical activity 1-2 hours before blood sampling is adequate when analyzing serum digoxin concentration in elderly outpatients, as everyday physical activity variations do not significantly affect steady-state levels.
Edner et al. (1994) studied this question.
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