Why the study?
It was unknown whether oral digoxin lowers muscle Na+,K+-ATPase, impairs muscle performance, and exacerbates exercise K+ disturbances in healthy humans.
Does digoxin 0.25 mg daily impair muscle performance and exacerbate exercise K+ disturbances in healthy adults?
Does digoxin 0.25 mg daily impair muscle performance and exacerbate exercise K+ disturbances in healthy adults?
In healthy adults, 14 days of clinical-dose digoxin reduced quadriceps muscle strength but did not reduce functional muscle NKA content or exacerbate K+ disturbances during intense exercise.
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Does not support digoxin impairing performance or NKA in healthy adults; leaves open effects in HF patients.
Sostaric et al. (2022) studied this question.
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