Key result
Low extracellular potassium accelerates the inotropic response to digoxin by ~92% versus normal levels.
Absolute Event Rate: 0.048% vs 0.025%
Extracellular potassium concentration inversely affects the rate of development of the inotropic response to digoxin, likely due to altered myocardial digoxin uptake.
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Hypothesis-generating for potassium effects on digoxin inotropy kinetics; leaves open clinical translation and requires validation.
PRINDLE et al. (1971) studied this question. Extracellular potassium concentration ([K]0) vs. Normal [K]0 (4.5 mM) was evaluated on Rate of change of the active tension response to digoxin (g/mm2 · min-1). Low extracellular potassium concentration increased the rate of development of the inotropic response to digoxin (0.048 vs 0.025 g/mm2·min-1), while high potassium decreased it (0.014 g/mm2·min-1).
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