Key result
Hyperkalemia markedly attenuated the inotropic effect of digoxin in dogs, increasing LV dp/dt by only 9.5% compared to 53.1% in normokalemic animals.
Why the study?
Does hyperkalemia alter the inotropic effects of digoxin in anesthetized dogs?
Does hyperkalemia alter the inotropic effects of digoxin in anesthetized dogs?
Absolute Event Rate: 9.5% vs 53.1%
Hyperkalemia attenuates the positive inotropic effects of digoxin by decreasing its binding to microsomal (Na+, K+)-ATPase.
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May attenuate digoxin inotropy in hyperkalemia; leaves open human relevance and clinical implications.
Goldman et al. (1973) studied Hyperkalemia. Digoxin in hyperkalemia vs. Digoxin in normokalemia was evaluated on Increase in the first derivative of the left ventricular pressure curve (LV dp/dt). Hyperkalemia markedly attenuated the inotropic effect of digoxin in dogs, increasing LV dp/dt by only 9.5% compared to 53.1% in normokalemic animals.
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