Why the study?
Does digoxin administration and subsequent reversal with digoxin-specific antibodies affect myocardial monovalent cation transport in dogs?
Does digoxin administration and subsequent reversal with digoxin-specific antibodies affect myocardial monovalent cation transport in dogs?
Digoxin causes dose-dependent inhibition of myocardial monovalent cation transport, which correlates with its inotropic and arrhythmogenic effects and is reversible with digoxin-specific antibodies.
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Links Na/K-ATPase inhibition to digoxin arrhythmias in dogs; leaves open translation to human toxicity management.
Hougen et al. (1979) studied this question.
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