June 1, 1972Journal of Clinical InvestigationOpen Access

The electrophysiologic effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin-specific antibody

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Why the study?

Does digoxin-specific antibody reverse the toxic electrophysiological effects of digoxin in isolated mammalian cardiac tissue?

Population

Isolated perfused cardiac tissue

Comparison

Digoxin-specific antibody perfused after… vs Various test solutions

Design

Preclinical

Follow-up

up to approximately 125 minutes

Authors

WMWilliam J. MandelElectrophysiology JBJ. Thomas BiggerElectrophysiology VBVincent P. ButlerColumbia University

Discussion

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Implication

DSA reverses digoxin toxicity in isolated tissue; hypothesis-generating and should not yet change clinical practice.

Structured PICO

Does digoxin-specific antibody reverse the toxic electrophysiological effects of digoxin in isolated mammalian cardiac tissue?

Population

Isolated perfused cardiac tissue (canine Purkinje fiber-ventricular muscle preparations and rabbit atrioventricular node preparations)

Intervention

Digoxin-specific antibody (DSA) perfused after exposure to 1 x 10(-7) M digoxin

Comparator

Various test solutions

Outcome

Reversal of digoxin-induced electrophysiological effects (including resting potential, action potential amplitude, rate of rise, overshoot, duration, membrane responsiveness, conduction velocity, and refractory period)surrogate

Digoxin-specific antibody effectively reverses the toxic electrophysiological effects of digoxin in isolated mammalian cardiac tissue.

Cite This Study

Mandel et al. (1972) studied this question.

synapsesocial.com/papers/6a912a93ca59a4cbdea1525a https://doi.org/10.1172/jci106933

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The electrophysiologic effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin-specific antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The electrophysiologic effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin-specific antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider