Why the study?
Does digoxin or deslanoside affect sinoatrial conduction time, atrial rate, and developed tension in isolated dog atria?
Population
Isolated dog atrial preparation perfused with heparinized blood from the carotid artery of an anesthetized…
Comparison
Digoxin or deslanoside given intravenously to… vs Baseline/control state prior to digitalis…
Design
Preclinical
Follow-up
Up to 75 minutes
Authors
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Animal data on dose-dependent atrial effects in dogs leave open human translation; no basis yet for clinical dosing changes.
Does digoxin or deslanoside affect sinoatrial conduction time, atrial rate, and developed tension in isolated dog atria?
Large doses of digitalis have no distinct immediate direct effect on SA nodal pacemaker activity and conductivity, though extremely large doses may eventually prolong sinoatrial conduction time.
Kobayashi et al. (1983) studied this question.
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