Why the study?
Do digoxin and deslanoside have a direct accelerating action on the SA node in canine models?
Population
Canine atria cross-perfused with heparinized arterial blood from donor dogs
Design
Preclinical
Follow-up
150 min
Authors
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No direct SA node acceleration by digoxin/deslanoside at inotropic doses in canines; leaves open human sinus node relevance.
Do digoxin and deslanoside have a direct accelerating action on the SA node in canine models?
Digoxin and deslanoside increase atrial developed tension without significant direct acceleration of the SA node except at extremely high doses.
Chiba et al. (1983) studied this question.
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