Key result
IV digoxin yields higher myocardial concentrations in volume-overloaded dogs versus normal dogs.
Why the study?
Does circulatory volume overload increase myocardial digoxin content in dogs?
Population
Dogs with circulatory volume overload induced by previous creation of aorto-caval fistulae
Comparison
Tritiated digoxin administered intravenously vs Normal dogs
Design
Preclinical
Follow-up
Up to 4 hours
Authors
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May increase myocardial digoxin in canine volume overload; hypothesis-generating, requires human studies before any clinical relevance.
Does circulatory volume overload increase myocardial digoxin content in dogs?
Circulatory volume overload increases myocardial digoxin concentration in dogs, potentially explaining reduced digitalis tolerance in this state.
Lloyd et al. (1976) studied Circulatory volume overload. Tritiated (12alpha-3H) digoxin vs. Normal dogs was evaluated on Myocardial digoxin concentration. Intravenous administration of digoxin in dogs with circulatory volume overload resulted in greater myocardial digoxin concentrations across all cardiac chambers compared to normal dogs.
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