Key result
Heart rate and RV work correlate with canine myocardial digoxin uptake, independent of blood flow.
Why the study?
Does myocardial mechanical activity and coronary blood flow influence myocardial digoxin uptake in open-chest dogs?
Population
Open-chest dogs
Design
Preclinical
Follow-up
60 min
Authors
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Suggests workload influences digoxin uptake in canine models; leaves open human relevance and clinical translation.
Does myocardial mechanical activity and coronary blood flow influence myocardial digoxin uptake in open-chest dogs?
Active myocardial uptake of cardiac glycosides is likely influenced by mechanical and metabolic activity rather than blood flow alone.
Lloyd et al. (1976) studied this question. Myocardial mechanical activity and coronary blood flow manipulation was evaluated on Myocardial digoxin uptake. Myocardial digoxin uptake in open-chest dogs correlated with heart rate and increased right ventricular mechanical work, but was not affected by increased regional myocardial blood flow.
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