Why the study?
Does heart rate influence digoxin-induced inhibition of myocardial Na+-K+-ATPase activity in sedated dogs?
Population
Sedated dogs
Comparison
Intravenous digoxin administration at paced… vs Intravenous digoxin administration at…
Design
Preclinical
Follow-up
60 min
Authors
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May suggest rate-dependent digoxin effects on Na-K-ATPase in dogs; leaves open translation to human arrhythmia risk.
Does heart rate influence digoxin-induced inhibition of myocardial Na+-K+-ATPase activity in sedated dogs?
Higher heart rates enhance the inhibition of myocardial Na+-K+-ATPase activity by digoxin in a canine model, which may increase the risk of digoxin-induced arrhythmias.
Marsh et al. (1981) studied this question.
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